Small-Conductance Calcium-Activated Potassium Current Is Activated During Hypokalemia and Masks Short-Term Cardiac Memory Induced by Ventricular Pacing | Zendy

YiHsin Chan | Zendy; Wei-Chung Tsai | Zendy; Jum Suk Ko | Zendy; Dechun Yin | Zendy; PoCheng Chang | Zendy; Michael Rubart | Zendy; James N. Weiss | Zendy; Thomas H. Everett | Zendy; ShienFong Lin | Zendy; PengSheng Chen | Zendy

Open Access

Small-Conductance Calcium-Activated Potassium Current Is Activated During Hypokalemia and Masks Short-Term Cardiac Memory Induced by Ventricular Pacing

Author(s) -

YiHsin Chan,

Wei-Chung Tsai,

Jum Suk Ko,

Dechun Yin,

PoCheng Chang,

Michael Rubart,

James N. Weiss,

Thomas H. Everett,

ShienFong Lin,

PengSheng Chen

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.015125

Subject(s) - apamin , hypokalemia , medicine , ventricular fibrillation , repolarization , cardiology , optical mapping , anesthesia , potassium channel , electrophysiology

Hypokalemia increases the vulnerability to ventricular fibrillation. We hypothesize that the apamin-sensitive small-conductance calcium-activated potassium current (IKAS) is activated during hypokalemia and that IKAS blockade is proarrhythmic.

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