Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia | Zendy

Takayuki Iriyama | Zendy; Kaiqi Sun | Zendy; Nicholas Parchim | Zendy; Jessica Li | Zendy; Cheng Zhao | Zendy; Anren Song | Zendy; Laura Hart | Zendy; Sean C. Blackwell | Zendy; Baha M. Sibai | Zendy; Lee-Nien L. Chan | Zendy; TehSheng Chan | Zendy; John Hicks | Zendy; Michael R. Blackburn | Zendy; Rodney E. Kellems | Zendy; Yang Xia | Zendy

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Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia

Author(s) -

Takayuki Iriyama,

Kaiqi Sun,

Nicholas Parchim,

Jessica Li,

Cheng Zhao,

Anren Song,

Laura Hart,

Sean C. Blackwell,

Baha M. Sibai,

Lee-Nien L. Chan,

TehSheng Chan,

John Hicks,

Michael R. Blackburn,

Rodney E. Kellems,

Yang Xia

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.013740

Subject(s) - preeclampsia , adenosine , medicine , pathogenesis , placenta , fetus , pregnancy , adenosine receptor , endocrinology , pathophysiology , placentation , receptor , biology , genetics , agonist

Preeclampsia is a prevalent hypertensive disorder of pregnancy and a leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic condition is speculated to be caused by placental abnormalities that contribute to the maternal syndrome. However, the specific factors and signaling pathways that lead to impaired placentas and maternal disease development remain elusive.

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