Proteasome-Mediated Reduction in Proapoptotic Molecule Bim Renders CD4 + CD28 null T Cells Resistant to Apoptosis in Acute Coronary Syndrome | Zendy

Edit Kovalcsik | Zendy; Ricardo Filipe da Silva Antunes | Zendy; Paramita Baruah | Zendy; Juan Carlos Kaski | Zendy; Ingrid E. Dumitriu | Zendy

Open Access

Proteasome-Mediated Reduction in Proapoptotic Molecule Bim Renders CD4 ⁺ CD28 ^null T Cells Resistant to Apoptosis in Acute Coronary Syndrome

Author(s) -

Edit Kovalcsik,

Ricardo Filipe da Silva Antunes,

Paramita Baruah,

Juan Carlos Kaski,

Ingrid E. Dumitriu

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.013710

Subject(s) - medicine , apoptosis , proteasome , acute coronary syndrome , reduction (mathematics) , cancer research , microbiology and biotechnology , biochemistry , myocardial infarction , biology , geometry , mathematics

The number of CD4(+)CD28(null) (CD28(null)) T cells, a unique subset of T lymphocytes with proinflammatory and cell-lytic phenotype, increases markedly in patients with acute coronary syndrome (ACS). ACS patients harboring high numbers of CD28(null) T cells have increased risk of recurrent severe acute coronary events and unfavorable prognosis. The mechanisms that govern the increase in CD28(null) T cells in ACS remain elusive. We investigated whether apoptosis pathways regulating T-cell homeostasis are perturbed in CD28(null) T cells in ACS.

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