Oxidative Stress Activates Endothelial Innate Immunity via Sterol Regulatory Element Binding Protein 2 (SREBP2) Transactivation of MicroRNA-92a | Zendy

Zhen Chen | Zendy; Liang Wen | Zendy; Marcy Martin | Zendy; ChienYi Hsu | Zendy; Longhou Fang | Zendy; Feng-Mao Lin | Zendy; Ting-Yang Lin | Zendy; McKenna J. Geary | Zendy; Greg G. Geary | Zendy; Yongli Zhao | Zendy; David A. Johnson | Zendy; JawWen Chen | Zendy; ShingJong Lin | Zendy; Shu Chien | Zendy; HsienDa Huang | Zendy; Yury I. Miller | Zendy; PoHsun Huang | Zendy; John Y.J. Shyy | Zendy

Open Access

Oxidative Stress Activates Endothelial Innate Immunity via Sterol Regulatory Element Binding Protein 2 (SREBP2) Transactivation of MicroRNA-92a

Author(s) -

Zhen Chen,

Liang Wen,

Marcy Martin,

ChienYi Hsu,

Longhou Fang,

Feng-Mao Lin,

Ting-Yang Lin,

McKenna J. Geary,

Greg G. Geary,

Yongli Zhao,

David A. Johnson,

JawWen Chen,

ShingJong Lin,

Shu Chien,

HsienDa Huang,

Yury I. Miller,

PoHsun Huang,

John Y.J. Shyy

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.013675

Subject(s) - endothelial dysfunction , innate immune system , oxidative stress , microbiology and biotechnology , transactivation , endothelium , endothelial stem cell , inflammasome , sirtuin 1 , biology , medicine , immunology , inflammation , transcription factor , immune system , biochemistry , downregulation and upregulation , gene , in vitro

Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase-derived nitric oxide bioavailability. Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which in turn activate endothelial innate immune response, leading to dysfunctional endothelium.

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