Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention | Zendy

Marion Jeanne | Zendy; Jeff Jorgensen | Zendy; Douglas B. Gould | Zendy

Open Access

Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention

Author(s) -

Marion Jeanne,

Jeff Jorgensen,

Douglas B. Gould

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.013395

Subject(s) - medicine , intracerebral hemorrhage , mutant , stroke (engine) , in vivo , phenotype , mutation , context (archaeology) , intracellular , pathology , pharmacology , microbiology and biotechnology , gene , biology , genetics , subarachnoid hemorrhage , mechanical engineering , paleontology , engineering

Collagen type IV alpha1 (COL4A1) and alpha2 (COL4A2) form heterotrimers critical for vascular basement membrane stability and function. Patients with COL4A1 or COL4A2 mutations suffer from diverse cerebrovascular diseases, including cerebral microbleeds, porencephaly, and fatal intracerebral hemorrhage (ICH). However, the pathogenic mechanisms remain unknown, and there is a lack of effective treatment.

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