Restoration of Impaired Endothelial Myocyte Enhancer Factor 2 Function Rescues Pulmonary Arterial Hypertension | Zendy

Jongmin Kim | Zendy; Cheol Hwangbo | Zendy; Xiaoyue Hu | Zendy; Yujung Kang | Zendy; Irinna Papangeli | Zendy; Devi Mehrotra | Zendy; Hyekyung Park | Zendy; Hyekyung Ju | Zendy; Danielle L. McLean | Zendy; Suzy Comhair | Zendy; Serpil C. Erzurum | Zendy; Hyung J. Chun | Zendy

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Restoration of Impaired Endothelial Myocyte Enhancer Factor 2 Function Rescues Pulmonary Arterial Hypertension

Author(s) -

Jongmin Kim,

Cheol Hwangbo,

Xiaoyue Hu,

Yujung Kang,

Irinna Papangeli,

Devi Mehrotra,

Hyekyung Park,

Hyekyung Ju,

Danielle L. McLean,

Suzy Comhair,

Serpil C. Erzurum,

Hyung J. Chun

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.013339

Subject(s) - mef2 , medicine , pulmonary hypertension , cancer research , myocardin , transcription factor , pulmonary artery , endothelial dysfunction , microrna , myocyte , enhancer , biology , serum response factor , gene , biochemistry

Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary arterioles, characterized by increased pulmonary arterial pressure and right ventricular failure. The cause of PAH is complex, but aberrant proliferation of the pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells is thought to play an important role in its pathogenesis. Understanding the mechanisms of transcriptional gene regulation involved in pulmonary vascular homeostasis can provide key insights into potential therapeutic strategies.

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