Regional Variation in Patients and Outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) Trial | Zendy

Marc A. Pfeffer | Zendy; Brian Claggett | Zendy; Susan F. Assmann | Zendy; Robin Boineau | Zendy; Inder S. Anand | Zendy; Nadine Clausell | Zendy; Akshay S. Desai | Zendy; Rafael Díaz | Zendy; Jerome L. Fleg | Zendy; И. Г. Гордеев | Zendy; John F. Heitner | Zendy; Eldrin F. Lewis | Zendy; Eileen O’Meara | Zendy; Jean-Lucien Rouleau | Zendy; Jeffrey L. Probstfield | Zendy; Tamaz Shaburishvili | Zendy; Sanjiv J. Shah | Zendy; Scott D. Solomon | Zendy; Nancy K. Sweitzer | Zendy; Sonja M. McKinlay | Zendy; Bertram Pitt | Zendy

Open Access

Regional Variation in Patients and Outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) Trial

Author(s) -

Marc A. Pfeffer,

Brian Claggett,

Susan F. Assmann,

Robin Boineau,

Inder S. Anand,

Nadine Clausell,

Akshay S. Desai,

Rafael Díaz,

Jerome L. Fleg,

И. Г. Гордеев,

John F. Heitner,

Eldrin F. Lewis,

Eileen O’Meara,

Jean-Lucien Rouleau,

Jeffrey L. Probstfield,

Tamaz Shaburishvili,

Sanjiv J. Shah,

Scott D. Solomon,

Nancy K. Sweitzer,

Sonja M. McKinlay,

Bertram Pitt

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.013255

Subject(s) - medicine , heart failure , aldosterone , antagonist , cardiology , cardiac function curve , receptor

Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) patients with heart failure and preserved left ventricular ejection fraction assigned to spironolactone did not achieve a significant reduction in the primary composite outcome (time to cardiovascular death, aborted cardiac arrest, or hospitalization for management of heart failure) compared with patients receiving placebo. In a post hoc analysis, an ≈4-fold difference was identified in this composite event rate between the 1678 patients randomized from Russia and Georgia compared with the 1767 enrolled from the United States, Canada, Brazil, and Argentina (the Americas).

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