East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina | Zendy

Yuji Mizuno | Zendy; Eisaku Harada | Zendy; Sumio Morita | Zendy; Kenji Kinoshita | Zendy; Mariko Hayashida | Zendy; Makoto Shono | Zendy; Yoshinobu MORIKAWA | Zendy; Toyoaki Murohara | Zendy; Masafumi Nakayama | Zendy; Michihiro Yoshimura | Zendy; Hirofumi Yasue | Zendy

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East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina

Author(s) -

Yuji Mizuno,

Eisaku Harada,

Sumio Morita,

Kenji Kinoshita,

Mariko Hayashida,

Makoto Shono,

Yoshinobu MORIKAWA,

Toyoaki Murohara,

Masafumi Nakayama,

Michihiro Yoshimura,

Hirofumi Yasue

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.013120

Subject(s) - medicine , aldh2 , gastroenterology , genotype , uric acid , creatine kinase , endocrinology , biochemistry , chemistry , gene

Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALDH2*2 genotype in Japanese.

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