Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction | Zendy

Payman Zamani | Zendy; Deepa Rawat | Zendy; Prithvi ShivaKumar | Zendy; Salvatore Geraci | Zendy; Rushik Bhuva | Zendy; Prasad Konda | Zendy; PaschalisThomas Doulias | Zendy; Harry Ischiropoulos | Zendy; Raymond R. Townsend | Zendy; Kenneth B. Margulies | Zendy; Thomas P. Cappola | Zendy; David C. Poole | Zendy; Julio A. Chirinos | Zendy

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Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction

Author(s) -

Payman Zamani,

Deepa Rawat,

Prithvi ShivaKumar,

Salvatore Geraci,

Rushik Bhuva,

Prasad Konda,

PaschalisThomas Doulias,

Harry Ischiropoulos,

Raymond R. Townsend,

Kenneth B. Margulies,

Thomas P. Cappola,

David C. Poole,

Julio A. Chirinos

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.012957

Subject(s) - medicine , nitric oxide , supine position , cardiac output , nitrite , ejection fraction , cardiology , crossover study , vasodilation , heart failure , placebo , cardiac index , vascular resistance , blood pressure , nitrate , chemistry , alternative medicine , organic chemistry , pathology

Inorganic nitrate (NO3(-)), abundant in certain vegetables, is converted to nitrite by bacteria in the oral cavity. Nitrite can be converted to nitric oxide in the setting of hypoxia. We tested the hypothesis that NO3(-) supplementation improves exercise capacity in heart failure with preserved ejection fraction via specific adaptations to exercise.

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