Effect of Repetitive Intra-Arterial Infusion of Bone Marrow Mononuclear Cells in Patients With No-Option Limb Ischemia | Zendy

Martin Teraa | Zendy; Ralf W. Sprengers | Zendy; Roger E. G. Schutgens | Zendy; Ineke SlaperCortenbach | Zendy; Yolanda van der Graaf | Zendy; Ale Algra | Zendy; Ingeborg van der Tweel | Zendy; Pieter A. Doevendans | Zendy; Willem P.Th.M. Mali | Zendy; Frans L. Moll | Zendy; Marianne C. Verhaar | Zendy

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Effect of Repetitive Intra-Arterial Infusion of Bone Marrow Mononuclear Cells in Patients With No-Option Limb Ischemia

Author(s) -

Martin Teraa,

Ralf W. Sprengers,

Roger E. G. Schutgens,

Ineke SlaperCortenbach,

Yolanda van der Graaf,

Ale Algra,

Ingeborg van der Tweel,

Pieter A. Doevendans,

Willem P.Th.M. Mali,

Frans L. Moll,

Marianne C. Verhaar

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.012913

Subject(s) - medicine , amputation , surgery , placebo , ischemia , confidence interval , randomized controlled trial , relative risk , anesthesia , bone marrow , pathology , alternative medicine

Patients with severe limb ischemia may not be eligible for conventional therapeutic interventions. Pioneering clinical trials suggest that bone marrow-derived cell therapy enhances neovascularization, improves tissue perfusion, and prevents amputation. The objective of this trial was to determine whether repetitive intra-arterial infusion of bone marrow mononuclear cells (BMMNCs) in patients with severe, nonrevascularizable limb ischemia can prevent major amputation.

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