Familial Clustering of Mitral Valve Prolapse in the Community | Zendy

Francesca N. Delling | Zendy; Jian Rong | Zendy; Martin G. Larson | Zendy; Birgitta T. Lehman | Zendy; Ewa Osypiuk | Zendy; Plamen Stantchev | Zendy; Susan A. Slaugenhaupt | Zendy; Emelia J. Benjamin | Zendy; Robert A. Levine | Zendy; Ramachandran S. Vasan | Zendy

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Familial Clustering of Mitral Valve Prolapse in the Community

Author(s) -

Francesca N. Delling,

Jian Rong,

Martin G. Larson,

Birgitta T. Lehman,

Ewa Osypiuk,

Plamen Stantchev,

Susan A. Slaugenhaupt,

Emelia J. Benjamin,

Robert A. Levine,

Ramachandran S. Vasan

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.012594

Subject(s) - medicine , mitral valve prolapse , odds ratio , confidence interval , spouse , offspring , pedigree chart , mitral valve , genetics , pregnancy , sociology , biology , anthropology , gene

Knowledge of mitral valve prolapse (MVP) inheritance is based on pedigree observation and M-mode echocardiography. The extent of familial clustering of MVP among unselected individuals in the community using current, more specific echocardiographic criteria is unknown. In addition, the importance of nondiagnostic MVP morphologies (NDMs; first described in large pedigrees) has not been investigated in the general population. We hypothesized that parental MVP and NDMs increase the risk of offspring MVP.

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