Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility | Zendy

Indira Medina | Zendy; Céline Cougoule | Zendy; Maik Drechsler | Zendy; Beatriz Bermúdez | Zendy; Rory R. Koenen | Zendy; Judith C. Sluimer | Zendy; Ine M. J. Wolfs | Zendy; Yvonne Döring | Zendy; Veronica Hérias | Zendy; Marjon Gijbels | Zendy; Ilze Bot | Zendy; Saskia C.A. de Jager | Zendy; Christian Weber | Zendy; Jack P.M. Cleutjens | Zendy; Theo J.C. van Berkel | Zendy; Kees-Jan Sikkink | Zendy; Atilla Mócsai | Zendy; Isabelle MaridonneauParini | Zendy; Oliver Soehnlein | Zendy; Erik A.L. Biessen | Zendy

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Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility

Author(s) -

Indira Medina,

Céline Cougoule,

Maik Drechsler,

Beatriz Bermúdez,

Rory R. Koenen,

Judith C. Sluimer,

Ine M. J. Wolfs,

Yvonne Döring,

Veronica Hérias,

Marjon Gijbels,

Ilze Bot,

Saskia C.A. de Jager,

Christian Weber,

Jack P.M. Cleutjens,

Theo J.C. van Berkel,

Kees-Jan Sikkink,

Atilla Mócsai,

Isabelle MaridonneauParini,

Oliver Soehnlein,

Erik A.L. Biessen

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.012316

Subject(s) - podosome , inflammation , monocyte , proinflammatory cytokine , haematopoiesis , microbiology and biotechnology , immunology , macrophage , pathology , chemistry , cancer research , biology , medicine , in vitro , stem cell , cell , cytoskeleton , biochemistry

Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte-derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated.

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