L-Kynurenine/Aryl Hydrocarbon Receptor Pathway Mediates Brain Damage After Experimental Stroke | Zendy

María Isabel Cuartero | Zendy; Iván Ballesteros | Zendy; Juan de la Parra | Zendy; Andrew L. Harkin | Zendy; Áine Abautret-Daly | Zendy; Eoin Sherwin | Zendy; Pedro M. FernándezSalguero | Zendy; Angel L. Corbı́ | Zendy; Ignacio Lizasoaín | Zendy; Marı́a A. Moro | Zendy

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L-Kynurenine/Aryl Hydrocarbon Receptor Pathway Mediates Brain Damage After Experimental Stroke

Author(s) -

María Isabel Cuartero,

Iván Ballesteros,

Juan de la Parra,

Andrew L. Harkin,

Áine Abautret-Daly,

Eoin Sherwin,

Pedro M. FernándezSalguero,

Angel L. Corbı́,

Ignacio Lizasoaín,

Marı́a A. Moro

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.011394

Subject(s) - aryl hydrocarbon receptor , neuroprotection , kynurenine , medicine , aryl hydrocarbon receptor nuclear translocator , receptor , in vivo , central nervous system , transcription factor , signal transduction , endogeny , pharmacology , microbiology and biotechnology , neuroscience , biology , biochemistry , tryptophan , genetics , gene , amino acid

Aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to the basic helix-loop-helix PAS (Per-Arnt-Sim homology domain) family known to mediate the toxic and carcinogenic effects of xenobiotics. Interestingly, AhR is widely expressed in the central nervous system, but its physiological and pathological roles are still unclear.

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