NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NFκB Signaling Pathways | Zendy

Qingwei Zhao | Zendy; Suryavathi Viswanadhapalli | Zendy; Paul J. Williams | Zendy; Qian Shi | Zendy; Chunyan Tan | Zendy; Xiaolan Yi | Zendy; Bhesh Bhandari | Zendy; Hanna E. Abboud | Zendy

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NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NFκB Signaling Pathways

Author(s) -

Qingwei Zhao,

Suryavathi Viswanadhapalli,

Paul J. Williams,

Qian Shi,

Chunyan Tan,

Xiaolan Yi,

Bhesh Bhandari,

Hanna E. Abboud

Publication year - 2015

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.011079

Subject(s) - medicine , pi3k/akt/mtor pathway , protein kinase b , signal transduction , nadph oxidase , fibrosis , nf κb , muscle hypertrophy , cancer research , microbiology and biotechnology , endocrinology , oxidative stress , inflammation , biology

NADPH oxidase 4 (Nox4) has been implicated in cardiac remodeling, but its precise role in cardiac injury remains controversial. Furthermore, little is known about the downstream effector signaling pathways activated by Nox4-derived reactive oxygen species in the myocardium. We investigated the role of Nox4 and Nox4-associated signaling pathways in the development of cardiac remodeling.

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