Paradoxical Muscle Sympathetic Reflex Activation in Human Heart Failure | Zendy

Philip J. Millar | Zendy; Hisayoshi Murai | Zendy; John S. Floras | Zendy

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Paradoxical Muscle Sympathetic Reflex Activation in Human Heart Failure

Author(s) -

Philip J. Millar,

Hisayoshi Murai,

John S. Floras

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.010765

Subject(s) - medicine , reflex , cardiology , heart failure , stroke volume , ejection fraction , blood pressure , heart rate , sympathetic nervous system , central venous pressure , anesthesia

Muscle sympathetic activation in heart failure with reduced ejection fraction (HFrEF) has been attributed, on the basis of multiunit recordings, to attenuated inhibitory feedback from stretch-sensitive cardiopulmonary mechanoreceptors. However, such preparations integrate 2 populations of single units exhibiting directionally opposite firing when atrial pressure is perturbed. We tested the hypothesis that the proportion of single units firing paradoxically when filling pressure increases is augmented in HFrEF.

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