Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca 2+ /Calmodulin-Dependent Protein Kinase II Signaling | Zendy

Malik Bisserier | Zendy; Magali Berthouze-Duquesnes | Zendy; Magali Breckler | Zendy; Florence Tortosa | Zendy; Loubina Fazal | Zendy; Annélie de Régibus | Zendy; AnneColine Laurent | Zendy; Audrey Varin | Zendy; Alexandre Lucas | Zendy; Maxime Branchereau | Zendy; Pauline Marck | Zendy; Jean-Nicolas Schickel | Zendy; Claudine Deloménie | Zendy; Olivier Cazorla | Zendy; Pauline SoulasSprauel | Zendy; Bertrand Crozatier | Zendy; Éric Morel | Zendy; Christophe Heymes | Zendy; Frank Lezoualc’h | Zendy

Open Access

Carabin Protects Against Cardiac Hypertrophy by Blocking Calcineurin, Ras, and Ca ²⁺ /Calmodulin-Dependent Protein Kinase II Signaling

Author(s) -

Malik Bisserier,

Magali Berthouze-Duquesnes,

Magali Breckler,

Florence Tortosa,

Loubina Fazal,

Annélie de Régibus,

AnneColine Laurent,

Audrey Varin,

Alexandre Lucas,

Maxime Branchereau,

Pauline Marck,

Jean-Nicolas Schickel,

Claudine Deloménie,

Olivier Cazorla,

Pauline SoulasSprauel,

Bertrand Crozatier,

Éric Morel,

Christophe Heymes,

Frank Lezoualc’h

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.010686

Subject(s) - calcineurin , pressure overload , medicine , signal transduction , endocrinology , calmodulin , microbiology and biotechnology , muscle hypertrophy , protein kinase a , kinase , biology , calcium , transplantation , cardiac hypertrophy

Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and is regulated by various signaling pathways. However, the molecular mechanisms that negatively regulate these signal transduction pathways remain poorly understood.

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