PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells | Zendy

Anthony A. Lanahan | Zendy; Diana Lech | Zendy; Alexandre Dubrac | Zendy; Jiasheng Zhang | Zendy; Zhen W. Zhuang | Zendy; Anne Eichmann | Zendy; Michael Simons | Zendy

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PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells

Author(s) -

Anthony A. Lanahan,

Diana Lech,

Alexandre Dubrac,

Jiasheng Zhang,

Zhen W. Zhuang,

Anne Eichmann,

Michael Simons

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.009683

Subject(s) - angiogenesis , arteriogenesis , vascular endothelial growth factor , microbiology and biotechnology , medicine , vascular endothelial growth factor b , vascular endothelial growth factor c , regulator , matrigel , kinase insert domain receptor , conditional gene knockout , signal transduction , endothelial stem cell , vascular endothelial growth factor a , knockout mouse , biology , cancer research , receptor , in vitro , vegf receptors , biochemistry , phenotype , gene

Regulation of vascular endothelial growth factor receptor-2 (VEGFR2) signaling is a control point that determines the extent of vascular tree formation. Recent studies demonstrated an important role played by VEGFR2 endothelial trafficking in control of its activity and suggested the involvement of a phosphotyrosine phosphatase 1b (PTP1b) in this process. This study was designed to define the role of PTP1b in endothelial VEGFR2 signaling and its role in regulation of angiogenesis and arteriogenesis.

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