Response to Letter Regarding Article “Inositol 1,4,5-Trisphosphate Receptors and Human Left Ventricular Myocytes” | Zendy

Sergio Signore | Zendy; Andrea Sorrentino | Zendy; João FerreiraMartins | Zendy; Ramaswamy Kannappan | Zendy; Mehrdad Shafaie | Zendy; Fabio Del Ben | Zendy; Kazuya Isobe | Zendy; Christian Arranto | Zendy; Ewa Wybieralska | Zendy; Andrew Webster | Zendy; Fumihiro Sanada | Zendy; Barbara Ogórek | Zendy; Hanqiao Zheng | Zendy; Xiaoxia Liu | Zendy; Federica del Monte | Zendy; David A. D’Alessandro | Zendy; Oriyanhan Wunimenghe | Zendy; Robert E. Michler | Zendy; Toru Hosoda | Zendy; Polina Goichberg | Zendy; Annarosa Leri | Zendy; Jan Kajstura | Zendy; Piero Anversa | Zendy; Marcello Rota | Zendy

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Response to Letter Regarding Article “Inositol 1,4,5-Trisphosphate Receptors and Human Left Ventricular Myocytes”

Author(s) -

Sergio Signore,

Andrea Sorrentino,

João FerreiraMartins,

Ramaswamy Kannappan,

Mehrdad Shafaie,

Fabio Del Ben,

Kazuya Isobe,

Christian Arranto,

Ewa Wybieralska,

Andrew Webster,

Fumihiro Sanada,

Barbara Ogórek,

Hanqiao Zheng,

Xiaoxia Liu,

Federica del Monte,

David A. D’Alessandro,

Oriyanhan Wunimenghe,

Robert E. Michler,

Toru Hosoda,

Polina Goichberg,

Annarosa Leri,

Jan Kajstura,

Piero Anversa,

Marcello Rota

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.114.009347

Subject(s) - medicine , medical school , inositol , receptor , gerontology , medical education

We thank Drs Heidrich and colleagues for their comments on our study discussing the role of inositol 1,4,5-trisphosphate receptors (IP3Rs) in ventricular myocytes.1 We documented that IP3Rs are present and operative in the rodent and human ventricular myocardium and that stimulation of Gαq-protein-coupled receptors promotes IP3R-mediated Ca2+ release. This adaptation provides inotropic support but favors electric instability.As pointed out by Dr Heidrich and colleagues, our report did not address the contribution of endogenous IP3R-regulatory proteins2 to the electrophysiological and contractile properties of ventricular myocytes. Specifically, they raised the possibility that chromogranin B, a sarcoplasmic reticulum Ca2+-binding protein, interacts with IP3Rs3 and modulates myocyte behavior after Gαq-protein-coupled receptor stimulation. The relationship between chromogranin B and IP3Rs …

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