Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients | Zendy

David Montaigne | Zendy; Xavier Maréchal | Zendy; Augustin Coisne | Zendy; Nicolas Debry | Zendy; Thomas Modine | Zendy; Georges Fayad | Zendy; Charlotte Potelle | Zendy; Jean-Marc El Arid | Zendy; S. Mouton | Zendy; Yasmine Sebti | Zendy; Hélène Duez | Zendy; Sébastien Preau | Zendy; Isabelle RémyJouet | Zendy; Farid Zerimech | Zendy; Mohamed Koussa | Zendy; Vincent Richard | Zendy; Rémi Névière | Zendy; JeanLouis Edmé | Zendy; Philippe Lefèbvre | Zendy; Bart Staels | Zendy

Open Access

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

Author(s) -

David Montaigne,

Xavier Maréchal,

Augustin Coisne,

Nicolas Debry,

Thomas Modine,

Georges Fayad,

Charlotte Potelle,

Jean-Marc El Arid,

S. Mouton,

Yasmine Sebti,

Hélène Duez,

Sébastien Preau,

Isabelle RémyJouet,

Farid Zerimech,

Mohamed Koussa,

Vincent Richard,

Rémi Névière,

JeanLouis Edmé,

Philippe Lefèbvre,

Bart Staels

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.008476

Subject(s) - medicine , insulin resistance , diabetic cardiomyopathy , endocrinology , diabetes mellitus , glycated hemoglobin , type 2 diabetes , mfn1 , type 2 diabetes mellitus , cardiomyopathy , oxidative stress , insulin , cardiology , mitochondrion , heart failure , mitochondrial fusion , mitochondrial dna , biology , biochemistry , gene , microbiology and biotechnology

Obesity and diabetes mellitus are independently associated with the development of heart failure. In this study, we determined the respective effects of obesity, insulin resistance, and diabetes mellitus on the intrinsic contraction and mitochondrial function of the human myocardium before the onset of cardiomyopathy.

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