Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice | Zendy

Dennis Wolf | Zendy; Felix Jehle | Zendy; Nathaly Anto Michel | Zendy; Éva Nóra Bukosza | Zendy; Jennifer Rivera | Zendy; YungChih Chen | Zendy; Natalie Hoppe | Zendy; Bianca Dufner | Zendy; Alexandra Ortiz Rodríguez | Zendy; Christian Colberg | Zendy; Leandro Nieto | Zendy; Benjamin Rupprecht | Zendy; Ansgar Wiedemann | Zendy; Lisa Schulte | Zendy; Alexander Peikert | Zendy; Nicole Bassler | Zendy; Andrey Lozhkin | Zendy; Sonja Hergeth | Zendy; Peter Stachon | Zendy; Ingo Hilgendorf | Zendy; Florian Willecke | Zendy; Constantin von zur Mühlen | Zendy; Dominik von Elverfeldt | Zendy; Christoph J. Binder | Zendy; Peter Aichele | Zendy; Nerea Varo | Zendy; Mark A. Febbraio | Zendy; Peter Libby | Zendy; Christoph Bode | Zendy; Karlheinz Peter | Zendy; Andreas Zirlik | Zendy

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Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice

Author(s) -

Dennis Wolf,

Felix Jehle,

Nathaly Anto Michel,

Éva Nóra Bukosza,

Jennifer Rivera,

YungChih Chen,

Natalie Hoppe,

Bianca Dufner,

Alexandra Ortiz Rodríguez,

Christian Colberg,

Leandro Nieto,

Benjamin Rupprecht,

Ansgar Wiedemann,

Lisa Schulte,

Alexander Peikert,

Nicole Bassler,

Andrey Lozhkin,

Sonja Hergeth,

Peter Stachon,

Ingo Hilgendorf,

Florian Willecke,

Constantin von zur Mühlen,

Dominik von Elverfeldt,

Christoph J. Binder,

Peter Aichele,

Nerea Varo,

Mark A. Febbraio,

Peter Libby,

Christoph Bode,

Karlheinz Peter,

Andreas Zirlik

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.008055

Subject(s) - proinflammatory cytokine , cd40 , adipose tissue , inflammation , endocrinology , medicine , metabolic syndrome , insulin resistance , immunology , biology , insulin , obesity , cytotoxic t cell , in vitro , biochemistry

Costimulatory cascades such as the CD40L-CD40 dyad enhance immune cell activation and inflammation during atherosclerosis. Here, we tested the hypothesis that CD40 directly modulates traits of the metabolic syndrome in diet-induced obesity in mice.

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