Inhibition of Glycosphingolipid Synthesis Ameliorates Atherosclerosis and Arterial Stiffness in Apolipoprotein E −/− Mice and Rabbits Fed a High-Fat and -Cholesterol Diet | Zendy

Subroto Chatterjee | Zendy; Djahida Bedja | Zendy; Sumita Mishra | Zendy; Christine Amuzie | Zendy; Alberto Avolio | Zendy; David A. Kass | Zendy; Dan E. Berkowitz | Zendy; Mark Renehan | Zendy

Open Access

Inhibition of Glycosphingolipid Synthesis Ameliorates Atherosclerosis and Arterial Stiffness in Apolipoprotein E ^−/− Mice and Rabbits Fed a High-Fat and -Cholesterol Diet

Author(s) -

Subroto Chatterjee,

Djahida Bedja,

Sumita Mishra,

Christine Amuzie,

Alberto Avolio,

David A. Kass,

Dan E. Berkowitz,

Mark Renehan

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.007559

Subject(s) - endocrinology , medicine , lactosylceramide , glycosphingolipid , lipoprotein , cholesterol , apolipoprotein b , apolipoprotein e , biology , biochemistry , enzyme , disease

Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing growth factor-initiated phenotypes. Here, we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atherosclerosis and arterial stiffness in transgenic mice and rabbits.

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