Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping | Zendy

Qing Lou | Zendy; Brian J. Hansen | Zendy; Olga Fedorenko | Zendy; Thomas A. Csepe | Zendy; Anuradha Kalyanasundaram | Zendy; Ning Li | Zendy; Lori T. Hage | Zendy; Alexey V. Glukhov | Zendy; George E. Billman | Zendy; Raul Weiss | Zendy; Peter J. Mohler | Zendy; Sándor Györke | Zendy; Brandon J. Biesiadecki | Zendy; Cynthia A. Carnes | Zendy; Vadim V. Fedorov | Zendy

Open Access

Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping

Author(s) -

Qing Lou,

Brian J. Hansen,

Olga Fedorenko,

Thomas A. Csepe,

Anuradha Kalyanasundaram,

Ning Li,

Lori T. Hage,

Alexey V. Glukhov,

George E. Billman,

Raul Weiss,

Peter J. Mohler,

Sándor Györke,

Brandon J. Biesiadecki,

Cynthia A. Carnes,

Vadim V. Fedorov

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.007086

Subject(s) - medicine , adenosine , atrial fibrillation , adenosine a1 receptor , cardiology , downregulation and upregulation , adenosine receptor , heart failure , endocrinology , receptor , agonist , biochemistry , gene , chemistry

Although sinoatrial node (SAN) dysfunction is a hallmark of human heart failure (HF), the underlying mechanisms remain poorly understood. We aimed to examine the role of adenosine in SAN dysfunction and tachy-brady arrhythmias in chronic HF.

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