Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating T Helper-1 Adaptive Immunity | Zendy

Ingo Hilgendorf | Zendy; Igor Theurl | Zendy; Louisa M.S. Gerhardt | Zendy; Clinton S. Robbins | Zendy; Georg F. Weber | Zendy; Ayelet Gonen | Zendy; Yoshiko Iwamoto | Zendy; Norbert Degousée | Zendy; Tobias A.W. Holderried | Zendy; Carla Winter | Zendy; Andreas Zirlik | Zendy; Herbert Y. Lin | Zendy; Galina K. Sukhova | Zendy; Jagdish Butany | Zendy; Barry B. Rubin | Zendy; Joseph L. Witztum | Zendy; Peter Libby | Zendy; Matthias Nahrendorf | Zendy; Ralph Weissleder | Zendy; Filip K. Świrski | Zendy

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Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating T Helper-1 Adaptive Immunity

Author(s) -

Ingo Hilgendorf,

Igor Theurl,

Louisa M.S. Gerhardt,

Clinton S. Robbins,

Georg F. Weber,

Ayelet Gonen,

Yoshiko Iwamoto,

Norbert Degousée,

Tobias A.W. Holderried,

Carla Winter,

Andreas Zirlik,

Herbert Y. Lin,

Galina K. Sukhova,

Jagdish Butany,

Barry B. Rubin,

Joseph L. Witztum,

Peter Libby,

Matthias Nahrendorf,

Ralph Weissleder,

Filip K. Świrski

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.006381

Subject(s) - immunology , acquired immune system , chemokine , immune system , macrophage , cd40 , population , innate immune system , b cell , microbiology and biotechnology , antigen presenting cell , medicine , biology , t cell , antibody , cytotoxic t cell , in vitro , biochemistry , environmental health

Atherosclerotic lesions grow via the accumulation of leukocytes and oxidized lipoproteins in the vessel wall. Leukocytes can attenuate or augment atherosclerosis through the release of cytokines, chemokines, and other mediators. Deciphering how leukocytes develop, oppose, and complement each other's function and shape the course of disease can illuminate our understanding of atherosclerosis. Innate response activator (IRA) B cells are a recently described population of granulocyte macrophage colony-stimulating factor-secreting cells of hitherto unknown function in atherosclerosis.

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