Microstructural Impact of Ischemia and Bone Marrow–Derived Cell Therapy Revealed With Diffusion Tensor Magnetic Resonance Imaging Tractography of the Heart In Vivo | Zendy

David E. Sosnovik | Zendy; Choukri Mekkaoui | Zendy; Shuning Huang | Zendy; Howard H. Chen | Zendy; Guangping Dai | Zendy; Christian T. Stoeck | Zendy; Soeun Ngoy | Zendy; Jian Guan | Zendy; Ruopeng Wang | Zendy; William J. Kostis | Zendy; Marcel P. Jackowski | Zendy; Van J. Wedeen | Zendy; Sebastian Kozerke | Zendy; Ronglih Liao | Zendy

Open Access

Microstructural Impact of Ischemia and Bone Marrow–Derived Cell Therapy Revealed With Diffusion Tensor Magnetic Resonance Imaging Tractography of the Heart In Vivo

Author(s) -

David E. Sosnovik,

Choukri Mekkaoui,

Shuning Huang,

Howard H. Chen,

Guangping Dai,

Christian T. Stoeck,

Soeun Ngoy,

Jian Guan,

Ruopeng Wang,

William J. Kostis,

Marcel P. Jackowski,

Van J. Wedeen,

Sebastian Kozerke,

Ronglih Liao

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.005841

Subject(s) - medicine , in vivo , magnetic resonance imaging , diffusion mri , fractional anisotropy , tractography , bone marrow , peripheral blood mononuclear cell , pathology , myocyte , ischemia , heart failure , cell , nuclear magnetic resonance , in vitro , radiology , chemistry , biology , biochemistry , physics , microbiology and biotechnology

The arrangement of myofibers in the heart is highly complex and must be replicated by injected cells to produce functional myocardium. A novel approach to characterize the microstructural response of the myocardium to ischemia and cell therapy, with the use of serial diffusion tensor magnetic resonance imaging tractography of the heart in vivo, is presented.

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