Survivin-Induced Abnormal Ploidy Contributes to Cystic Kidney and Aneurysm Formation | Zendy

Wissam A. AbouAlaiwi | Zendy; Brian S. Muntean | Zendy; Shobha Ratnam | Zendy; Bina Joe | Zendy; Lijun Liu | Zendy; Robert L. Booth | Zendy; Ingrid Rodrı́guez | Zendy; B. Herbert | Zendy; Robert L. Bacallao | Zendy; Marcus Fruttiger | Zendy; Tak W. Mak | Zendy; Jing Zhou | Zendy; Surya M. Nauli | Zendy

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Survivin-Induced Abnormal Ploidy Contributes to Cystic Kidney and Aneurysm Formation

Author(s) -

Wissam A. AbouAlaiwi,

Brian S. Muntean,

Shobha Ratnam,

Bina Joe,

Lijun Liu,

Robert L. Booth,

Ingrid Rodrı́guez,

B. Herbert,

Robert L. Bacallao,

Marcus Fruttiger,

Tak W. Mak,

Jing Zhou,

Surya M. Nauli

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.005746

Subject(s) - medicine , survivin , kidney , ploidy , aneurysm , pathology , cancer research , immunology , genetics , radiology , cancer , gene , biology

Cystic kidneys and vascular aneurysms are clinical manifestations seen in patients with polycystic kidney disease, a cilia-associated pathology (ciliopathy). Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or knockout has never been studied before. The present studies aim to examine whether and how cilia function (Pkd1 or Pkd2) and structure (Tg737) play a role in cystic kidney and aneurysm through survivin downregulation.

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