Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation | Zendy

Deli Zhang | Zendy; Chia-Tung Wu | Zendy; Xiaoyan Qi | Zendy; Roelien A. M. Meijering | Zendy; Femke HoogstraBerends | Zendy; Artavazd Tadevosyan | Zendy; Günseli Çubukçuoğlu Deniz | Zendy; Serkan Durdu | Zendy; Ahmet Rüçhan Akar | Zendy; Ody C.M. Sibon | Zendy; Stanley Nattel | Zendy; Robert H. Henning | Zendy; Bianca J.J.M. Brundel | Zendy

Open Access

Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation

Author(s) -

Deli Zhang,

Chia-Tung Wu,

Xiaoyan Qi,

Roelien A. M. Meijering,

Femke HoogstraBerends,

Artavazd Tadevosyan,

Günseli Çubukçuoğlu Deniz,

Serkan Durdu,

Ahmet Rüçhan Akar,

Ody C.M. Sibon,

Stanley Nattel,

Robert H. Henning,

Bianca J.J.M. Brundel

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.005300

Subject(s) - hdac6 , proteostasis , acetylation , medicine , histone deacetylase , histone deacetylase inhibitor , contractility , microbiology and biotechnology , microtubule , hdac4 , cancer research , pharmacology , histone , biology , biochemistry , gene

Atrial fibrillation (AF) is characterized by structural remodeling, contractile dysfunction, and AF progression. Histone deacetylases (HDACs) influence acetylation of both histones and cytosolic proteins, thereby mediating epigenetic regulation and influencing cell proteostasis. Because the exact function of HDACs in AF is unknown, we investigated their role in experimental and clinical AF models.

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