Aldose Reductase–Mediated Phosphorylation of p53 Leads to Mitochondrial Dysfunction and Damage in Diabetic Platelets | Zendy

Wai Ho Tang | Zendy; Jeremiah Stitham | Zendy; Jin Yu | Zendy; Renjing Liu | Zendy; Seung Hee Lee | Zendy; Jing Du | Zendy; Gourg Atteya | Zendy; Scott Gleim | Zendy; Geralyn Spollett | Zendy; Kathleen A. Martin | Zendy; John Hwa | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Aldose Reductase–Mediated Phosphorylation of p53 Leads to Mitochondrial Dysfunction and Damage in Diabetic Platelets

Author(s) -

Wai Ho Tang,

Jeremiah Stitham,

Jin Yu,

Renjing Liu,

Seung Hee Lee,

Jing Du,

Gourg Atteya,

Scott Gleim,

Geralyn Spollett,

Kathleen A. Martin,

John Hwa

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.005224

Subject(s) - aldose reductase , mitochondrion , reactive oxygen species , platelet , medicine , diabetes mellitus , hyperactivation , endocrinology , apoptosis , platelet activation , microbiology and biotechnology , biology , biochemistry

Platelet abnormalities are well-recognized complications of diabetes mellitus. Mitochondria play a central role in platelet metabolism and activation. Mitochondrial dysfunction is evident in diabetes mellitus. The molecular pathway for hyperglycemia-induced mitochondrial dysfunction in platelets in diabetes mellitus is unknown.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research