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Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus
Author(s) -
David Z.I. Cherney,
Bruce A. Perkins,
Nima Soleymanlou,
M Maione,
Vesta Lai,
Alana Lee,
Nora Fagan,
Hans J. Woerle,
Odd Erik Johansen,
Uli C. Broedl,
Maximilian von Eynatten
Publication year - 2013
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.113.005081
Subject(s) - empagliflozin , medicine , renal function , glomerular hyperfiltration , effective renal plasma flow , endocrinology , renal blood flow , diabetes mellitus , tubuloglomerular feedback , plasma renin activity , aldosterone , filtration fraction , type 2 diabetes , urology , renin–angiotensin system , blood pressure , diabetic nephropathy
The primary objective of this mechanistic open-label, stratified clinical trial was to determine the effect of 8 weeks' sodium glucose cotransporter 2 inhibition with empagliflozin 25 mg QD on renal hyperfiltration in subjects with type 1 diabetes mellitus (T1D).

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