Endothelial Cell–Specific Reactive Oxygen Species Production Increases Susceptibility to Aortic Dissection | Zendy

Lampson Fan | Zendy; Gillian Douglas | Zendy; Jennifer K. Bendall | Zendy; Eileen McNeill | Zendy; Mark J. Crabtree | Zendy; Ashley Hale | Zendy; Anna Mai | Zendy; JianMei Li | Zendy; Martina A. McAteer | Zendy; Jürgen E. Schneider | Zendy; Robin P. Choudhury | Zendy; Keith M. Chan | Zendy

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Endothelial Cell–Specific Reactive Oxygen Species Production Increases Susceptibility to Aortic Dissection

Author(s) -

Lampson Fan,

Gillian Douglas,

Jennifer K. Bendall,

Eileen McNeill,

Mark J. Crabtree,

Ashley Hale,

Anna Mai,

JianMei Li,

Martina A. McAteer,

Jürgen E. Schneider,

Robin P. Choudhury,

Keith M. Chan

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.005062

Subject(s) - vascular smooth muscle , cypa , reactive oxygen species , microbiology and biotechnology , angiotensin ii , medicine , endothelial stem cell , endothelium , biology , immunology , receptor , biochemistry , in vitro , human immunodeficiency virus (hiv) , smooth muscle

Increased production of reactive oxygen species (ROS) throughout the vascular wall is a feature of cardiovascular disease states, but therapeutic strategies remain limited by our incomplete understanding of the role and contribution of specific vascular cell ROS to disease pathogenesis. To investigate the specific role of endothelial cell (EC) ROS in the development of structural vascular disease, we generated a mouse model of endothelium-specific Nox2 overexpression and tested the susceptibility to aortic dissection after angiotensin II (Ang II) infusion.

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