Atrium-Specific Kir3.x Determines Inducibility, Dynamics, and Termination of Fibrillation by Regulating Restitution-Driven Alternans | Zendy

Brian O. Bingen | Zendy; Zeinab Neshati | Zendy; Saïd F.A. Askar | Zendy; Ivan V. Kazbanov | Zendy; Dirk L. Ypey | Zendy; Alexander V. Panfilov | Zendy; Martin J. Schalij | Zendy; Antoine A.F. de Vries | Zendy; Daniël A. Pijnappels | Zendy

Open Access

Atrium-Specific Kir3.x Determines Inducibility, Dynamics, and Termination of Fibrillation by Regulating Restitution-Driven Alternans

Author(s) -

Brian O. Bingen,

Zeinab Neshati,

Saïd F.A. Askar,

Ivan V. Kazbanov,

Dirk L. Ypey,

Alexander V. Panfilov,

Martin J. Schalij,

Antoine A.F. de Vries,

Daniël A. Pijnappels

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.005019

Subject(s) - restitution , medicine , atrial fibrillation , fibrillation , cardiology , atrium (architecture) , law , political science

Atrial fibrillation is the most common cardiac arrhythmia. Ventricular proarrhythmia hinders pharmacological atrial fibrillation treatment. Modulation of atrium-specific Kir3.x channels, which generate a constitutively active current (I(K,ACh-c)) after atrial remodeling, might circumvent this problem. However, it is unknown whether and how I(K,ACh-c) contributes to atrial fibrillation induction, dynamics, and termination. Therefore, we investigated the effects of I(K,ACh-c) blockade and Kir3.x downregulation on atrial fibrillation.

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