Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis | Zendy

Sima Allahverdian | Zendy; Ali Cyrus Chehroudi | Zendy; Bruce M. McManus | Zendy; Thomas Abraham | Zendy; Gordon A. Francis | Zendy

Open Access

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

Author(s) -

Sima Allahverdian,

Ali Cyrus Chehroudi,

Bruce M. McManus,

Thomas Abraham,

Gordon A. Francis

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.005015

Subject(s) - abca1 , foam cell , medicine , macrophage , cd68 , coronary atherosclerosis , population , cholesterol , myeloid , pathology , immunology , biology , coronary artery disease , immunohistochemistry , lipoprotein , biochemistry , in vitro , environmental health , transporter , gene

Intimal smooth muscle cells (SMCs) contribute to the foam cell population in arterial plaque, and express lower levels of the cholesterol exporter ATP-binding cassette transporter A1 (ABCA1) in comparison with medial arterial SMCs. The relative contribution of SMCs to the total foam cell population and their expression of ABCA1 in comparison with intimal monocyte-derived macrophages, however, are unknown. Although the expression of macrophage markers by SMCs following lipid loading has been described, the relevance of this phenotypic switch by SMCs in human coronary atherosclerosis has not been determined.

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