Age-Associated Defects in EphA2 Signaling Impair the Migration of Human Cardiac Progenitor Cells | Zendy

Polina Goichberg | Zendy; Ramaswamy Kannappan | Zendy; Maria Cimini | Zendy; Yingnan Bai | Zendy; Fumihiro Sanada | Zendy; Andrea Sorrentino | Zendy; Sergio Signore | Zendy; Jan Kajstura | Zendy; Marcello Rota | Zendy; Piero Anversa | Zendy; Annarosa Leri | Zendy

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Age-Associated Defects in EphA2 Signaling Impair the Migration of Human Cardiac Progenitor Cells

Author(s) -

Polina Goichberg,

Ramaswamy Kannappan,

Maria Cimini,

Yingnan Bai,

Fumihiro Sanada,

Andrea Sorrentino,

Sergio Signore,

Jan Kajstura,

Marcello Rota,

Piero Anversa,

Annarosa Leri

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.004698

Subject(s) - eph receptor a2 , microbiology and biotechnology , erythropoietin producing hepatocellular (eph) receptor , ephrin , endocytic cycle , progenitor cell , biology , medicine , receptor , endocytosis , signal transduction , cancer research , stem cell , receptor tyrosine kinase

Aging negatively impacts on the function of resident human cardiac progenitor cells (hCPCs). Effective regeneration of the injured heart requires mobilization of hCPCs to the sites of damage. In the young heart, signaling by the guidance receptor EphA2 in response to the ephrin A1 ligand promotes hCPC motility and improves cardiac recovery after infarction.

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