Novel Small Leucine-Rich Repeat Protein Podocan Is a Negative Regulator of Migration and Proliferation of Smooth Muscle Cells, Modulates Neointima Formation, and Is Expressed in Human Atheroma | Zendy

Randolph Hutter | Zendy; Li Huang | Zendy; Walter S. Speidl | Zendy; Chiara Giannarelli | Zendy; Paul Trubin | Zendy; Gerhard Bauriedel | Zendy; Mary E. Klotman | Zendy; Valentı́n Fuster | Zendy; Juan J. Badimón | Zendy; Paul E. Klotman | Zendy

Open Access

Novel Small Leucine-Rich Repeat Protein Podocan Is a Negative Regulator of Migration and Proliferation of Smooth Muscle Cells, Modulates Neointima Formation, and Is Expressed in Human Atheroma

Author(s) -

Randolph Hutter,

Li Huang,

Walter S. Speidl,

Chiara Giannarelli,

Paul Trubin,

Gerhard Bauriedel,

Mary E. Klotman,

Valentı́n Fuster,

Juan J. Badimón,

Paul E. Klotman

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.004634

Subject(s) - neointima , wnt signaling pathway , cell growth , vascular smooth muscle , medicine , microbiology and biotechnology , downregulation and upregulation , biology , transfection , cancer research , pathology , endocrinology , signal transduction , cell culture , gene , restenosis , biochemistry , genetics , smooth muscle , stent

Smooth muscle cell (SMC) migration and proliferation critically influence the clinical course of vascular disease. We tested the effect of the novel small leucine-rich repeat protein podocan on SMC migration and proliferation using a podocan-deficient mouse in combination with a model of arterial injury and aortic explant SMC culture. In addition, we examined the effect of overexpression of the human form of podocan on human SMCs and tested for podocan expression in human atherosclerosis. In all these conditions, we concomitantly evaluated the Wnt-TCF (T-cell factor) pathway.

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