Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis
Author(s) -
Martin M.N. Schmitt,
Remco T. A. Megens,
Alma Zernecke,
Kiril Bidzhekov,
Nynke M. S. van den Akker,
Timo Rademakers,
Marc A. van Zandvoort,
Tilman M. Hackeng,
Rory R. Koenen,
Christian Weber
Publication year - 2013
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.113.004149
Subject(s) - leukocyte extravasation , cell adhesion molecule , medicine , endothelium , extravasation , microbiology and biotechnology , endothelial stem cell , bone marrow , monocyte , inflammation , lesion , vascular permeability , immunology , pathology , biology , in vitro , biochemistry
Junctional adhesion molecule (JAM)-A expressed in endothelial, epithelial, and blood cells can regulate permeability and leukocyte extravasation. Atherosclerosis develops at sites of disturbed flow in large arteries, but the mechanisms guiding inflammatory cells into these predilection sites remain unknown.
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