Endothelial Fate Mapping in Mice With Pulmonary Hypertension | Zendy

Lina Qiao | Zendy; Toshihiko Nishimura | Zendy; Lingfang Shi | Zendy; Dane Sessions | Zendy; Ama Thrasher | Zendy; James R. Trudell | Zendy; Gerald J. Berry | Zendy; Ronald G. Pearl | Zendy; Peter N. Kao | Zendy

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Endothelial Fate Mapping in Mice With Pulmonary Hypertension

Author(s) -

Lina Qiao,

Toshihiko Nishimura,

Lingfang Shi,

Dane Sessions,

Ama Thrasher,

James R. Trudell,

Gerald J. Berry,

Ronald G. Pearl,

Peter N. Kao

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.003734

Subject(s) - neointima , medicine , pulmonary artery , pulmonary hypertension , vascular smooth muscle , cd31 , endothelium , pathology , cardiology , immunohistochemistry , restenosis , stent , smooth muscle

Pulmonary endothelial injury triggers a reparative program, which in susceptible individuals is characterized by neointima formation, vascular narrowing, and the development of pulmonary arterial hypertension. The neointimal cells in human pathological plexiform lesions frequently coexpress smooth muscle α-actin and the endothelial von Willebrand antigen, creating a question about their cellular lineage of origin.

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