Unexpected Effect of Proton Pump Inhibitors | Zendy

Yohannes T. Ghebremariam | Zendy; Paea LePendu | Zendy; Jerry C. Lee | Zendy; Daniel A. Erlanson | Zendy; Anna Slaviero | Zendy; Nigam H. Shah | Zendy; James Leiper | Zendy; John P. Cooke | Zendy

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Unexpected Effect of Proton Pump Inhibitors

Author(s) -

Yohannes T. Ghebremariam,

Paea LePendu,

Jerry C. Lee,

Daniel A. Erlanson,

Anna Slaviero,

Nigam H. Shah,

James Leiper,

John P. Cooke

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.003602

Subject(s) - medicine , asymmetric dimethylarginine , vasoprotective , nitric oxide , population , adverse effect , nitric oxide synthase , pharmacology , disease , cardiology , arginine , biochemistry , chemistry , environmental health , amino acid

Proton pump inhibitors (PPIs) are gastric acid-suppressing agents widely prescribed for the treatment of gastroesophageal reflux disease. Recently, several studies in patients with acute coronary syndrome have raised the concern that use of PPIs in these patients may increase their risk of major adverse cardiovascular events. The mechanism of this possible adverse effect is not known. Whether the general population might also be at risk has not been addressed.

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