Oxidized Ca 2+ /Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation | Zendy

Anil Purohit | Zendy; Adam G. Rokita | Zendy; Xiaoqun Guan | Zendy; Biyi Chen | Zendy; Olha M. Koval | Zendy; Niels Voigt | Zendy; Stefan Neef | Zendy; Thomas Sowa | Zendy; Zhan Gao | Zendy; Elizabeth D. Luczak | Zendy; Hrafnhildur Stefansdottir | Zendy; Andrew C. Behunin | Zendy; Na Li | Zendy; Ramzi El Accaoui | Zendy; Baoli Yang | Zendy; Paari Dominic Swaminathan | Zendy; Robert M. Weiss | Zendy; Xander H.T. Wehrens | Zendy; LongSheng Song | Zendy; Dobromir Dobrev | Zendy; Lars S. Maier | Zendy; Mark E. Anderson | Zendy

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Oxidized Ca ²⁺ /Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation

Author(s) -

Anil Purohit,

Adam G. Rokita,

Xiaoqun Guan,

Biyi Chen,

Olha M. Koval,

Niels Voigt,

Stefan Neef,

Thomas Sowa,

Zhan Gao,

Elizabeth D. Luczak,

Hrafnhildur Stefansdottir,

Andrew C. Behunin,

Na Li,

Ramzi El Accaoui,

Baoli Yang,

Paari Dominic Swaminathan,

Robert M. Weiss,

Xander H.T. Wehrens,

LongSheng Song,

Dobromir Dobrev,

Lars S. Maier,

Mark E. Anderson

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.003313

Subject(s) - reactive oxygen species , angiotensin ii , medicine , endocrinology , genetically modified mouse , calmodulin , sinus rhythm , atrial fibrillation , protein kinase a , renin–angiotensin system , transgene , kinase , receptor , biochemistry , chemistry , calcium , gene , blood pressure

Atrial fibrillation (AF) is a growing public health problem without adequate therapies. Angiotensin II and reactive oxygen species are validated risk factors for AF in patients, but the molecular pathways connecting reactive oxygen species and AF are unknown. The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) has recently emerged as a reactive oxygen species-activated proarrhythmic signal, so we hypothesized that oxidized CaMKIIδ could contribute to AF.

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