Population Pharmacokinetics of Enoxaparin During the Antenatal Period | Zendy

Jignesh P. Patel | Zendy; Bruce Green | Zendy; Raj Patel | Zendy; M. S. Marsh | Zendy; Graham Davies | Zendy; Roopen Arya | Zendy

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Population Pharmacokinetics of Enoxaparin During the Antenatal Period

Author(s) -

Jignesh P. Patel,

Bruce Green,

Raj Patel,

M. S. Marsh,

Graham Davies,

Roopen Arya

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.003198

Subject(s) - medicine , pharmacokinetics , population , period (music) , population pharmacokinetics , pediatrics , obstetrics , pharmacology , environmental health , physics , acoustics

The optimal dosing strategy of low-molecular-weight heparins for the treatment of antenatal venous thromboembolism is not known. The physiological changes associated with pregnancy alter the pharmacokinetic profile of low-molecular-weight heparins, which has led to controversy and subsequent variation in practice, when pregnant women with venous thromboembolism are treated with low-molecular-weight heparins. Our objective was to develop a robust pharmacokinetic model of enoxaparin during the antenatal period to address this problem.

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