Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity | Zendy

Renjing Liu | Zendy; Jin Yu | Zendy; Wai Ho Tang | Zendy; Lingfeng Qin | Zendy; Xinbo Zhang | Zendy; George Tellides | Zendy; John Hwa | Zendy; Jun Yu | Zendy; Kathleen A. Martin | Zendy

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Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity

Author(s) -

Renjing Liu,

Jin Yu,

Wai Ho Tang,

Lingfeng Qin,

Xinbo Zhang,

George Tellides,

John Hwa,

Jun Yu,

Kathleen A. Martin

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002887

Subject(s) - myocardin , gene knockdown , klf4 , epigenetics , chromatin immunoprecipitation , biology , microbiology and biotechnology , chromatin , regulation of gene expression , cancer research , transcriptional regulation , promoter , serum response factor , gene expression , gene , transcription factor , genetics , sox2

Smooth muscle cells (SMCs) are remarkably plastic. Their reversible differentiation is required for growth and wound healing but also contributes to pathologies such as atherosclerosis and restenosis. Although key regulators of the SMC phenotype, including myocardin (MYOCD) and KLF4, have been identified, a unifying epigenetic mechanism that confers reversible SMC differentiation has not been reported.

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