Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction | Zendy

Konstantinos Malliaras | Zendy; Rachel Smith | Zendy; Hideaki Kanazawa | Zendy; Kristine Yee | Zendy; Jeffrey Seinfeld | Zendy; Eleni Tseliou | Zendy; James Dawkins | Zendy; Michelle Kreke | Zendy; Ke Cheng | Zendy; Daniel Luthringer | Zendy; ChakSum Ho | Zendy; Agnieszka Blusztajn | Zendy; Ileana Valle | Zendy; Supurna Chowdhury | Zendy; Raj Makkar | Zendy; Rohan Dharmakumar | Zendy; Debiao Li | Zendy; Linda Marbán | Zendy; Eduardo Marbán | Zendy

Open Access

Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction

Author(s) -

Konstantinos Malliaras,

Rachel Smith,

Hideaki Kanazawa,

Kristine Yee,

Jeffrey Seinfeld,

Eleni Tseliou,

James Dawkins,

Michelle Kreke,

Ke Cheng,

Daniel Luthringer,

ChakSum Ho,

Agnieszka Blusztajn,

Ileana Valle,

Supurna Chowdhury,

Raj Makkar,

Rohan Dharmakumar,

Debiao Li,

Linda Marbán,

Eduardo Marbán

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002863

Subject(s) - medicine , magnetic resonance imaging , myocardial infarction , cell therapy , cardiology , ventricular remodeling , stem cell , regeneration (biology) , regenerative medicine , stem cell therapy , pathology , transplantation , radiology , biology , genetics , microbiology and biotechnology

Magnetic resonance imaging (MRI) in the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction (CADUCEUS) trial revealed that cardiosphere-derived cells (CDCs) decrease scar size and increase viable myocardium after myocardial infarction (MI), but MRI has not been validated as an index of regeneration after cell therapy. We tested the validity of contrast-enhanced MRI in quantifying scarred and viable myocardium after cell therapy in a porcine model of convalescent MI.

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