CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation | Zendy

Michael Jeltsch | Zendy; Sawan Kumar Jha | Zendy; Denis Tvorogov | Zendy; Andrey Anisimov | Zendy; VeliMatti Leppänen | Zendy; Tanja Holopainen | Zendy; Riikka Kivelä | Zendy; Sagrario Ortega | Zendy; Terhi Kärpänen | Zendy; Kari Alitalo | Zendy

Open Access

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

Author(s) -

Michael Jeltsch,

Sawan Kumar Jha,

Denis Tvorogov,

Andrey Anisimov,

VeliMatti Leppänen,

Tanja Holopainen,

Riikka Kivelä,

Sagrario Ortega,

Terhi Kärpänen,

Kari Alitalo

Publication year - 2014

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002779

Subject(s) - lymphangiogenesis , vascular endothelial growth factor c , angiogenesis , biology , vascular endothelial growth factor , disintegrin , vascular endothelial growth factor b , microbiology and biotechnology , neuropilin 1 , cancer research , vascular endothelial growth factor a , growth factor , metalloproteinase , receptor , matrix metalloproteinase , genetics , metastasis , cancer , vegf receptors

Hennekam lymphangiectasia-lymphedema syndrome (Online Mendelian Inheritance in Man 235510) is a rare autosomal recessive disease, which is associated with mutations in the CCBE1 gene. Because of the striking phenotypic similarity of embryos lacking either the Ccbe1 gene or the lymphangiogenic growth factor Vegfc gene, we searched for collagen- and calcium-binding epidermal growth factor domains 1 (CCBE1) interactions with the vascular endothelial growth factor-C (VEGF-C) growth factor signaling pathway, which is critical in embryonic and adult lymphangiogenesis.

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