Inositol 1, 4, 5-Trisphosphate Receptors and Human Left Ventricular Myocytes | Zendy

Sergio Signore | Zendy; Andrea Sorrentino | Zendy; João FerreiraMartins | Zendy; Ramaswamy Kannappan | Zendy; Mehrdad Shafaie | Zendy; Fabio Del Ben | Zendy; Kazuya Isobe | Zendy; Christian Arranto | Zendy; Ewa Wybieralska | Zendy; Andrew Webster | Zendy; Fumihiro Sanada | Zendy; Barbara Ogórek | Zendy; Hanqiao Zheng | Zendy; Xiaoxia Liu | Zendy; Federica del Monte | Zendy; David A. D’Alessandro | Zendy; Oriyanhan Wunimenghe | Zendy; Robert E. Michler | Zendy; Toru Hosoda | Zendy; Polina Goichberg | Zendy; Annarosa Leri | Zendy; Jan Kajstura | Zendy; Piero Anversa | Zendy; Marcello Rota | Zendy

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Inositol 1, 4, 5-Trisphosphate Receptors and Human Left Ventricular Myocytes

Author(s) -

Sergio Signore,

Andrea Sorrentino,

João FerreiraMartins,

Ramaswamy Kannappan,

Mehrdad Shafaie,

Fabio Del Ben,

Kazuya Isobe,

Christian Arranto,

Ewa Wybieralska,

Andrew Webster,

Fumihiro Sanada,

Barbara Ogórek,

Hanqiao Zheng,

Xiaoxia Liu,

Federica del Monte,

David A. D’Alessandro,

Oriyanhan Wunimenghe,

Robert E. Michler,

Toru Hosoda,

Polina Goichberg,

Annarosa Leri,

Jan Kajstura,

Piero Anversa,

Marcello Rota

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002764

Subject(s) - myocyte , ryanodine receptor , receptor , inositol , medicine , endoplasmic reticulum , endocrinology , afterdepolarization , gq alpha subunit , inositol trisphosphate receptor , stimulation , microbiology and biotechnology , biology , electrophysiology , g protein , repolarization

Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the adult heart experimentally. Moreover, whether these Ca(2+) release channels are present and play a critical role in human cardiomyocytes remains to be defined. IP3Rs may be activated after Gαq-protein-coupled receptor stimulation, affecting Ca(2+) cycling, enhancing myocyte performance, and potentially favoring an increase in the incidence of arrhythmias.

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