Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility | Zendy

Han Xiao | Zendy; Min Lü | Zendy; Ting Yang Lin | Zendy; Zhen Chen | Zendy; Gang Chen | Zendy; Wei-Chi Wang | Zendy; Traci Marin | Zendy; TzuPin Shentu | Zendy; Liang Wen | Zendy; Brendan Gongol | Zendy; Wei Sun | Zendy; Xiao Liang | Zendy; Ju Chen | Zendy; HsienDa Huang | Zendy; Joao H. F. Pedra | Zendy; David A. Johnson | Zendy; John Y.J. Shyy | Zendy

Open Access

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

Author(s) -

Han Xiao,

Min Lü,

Ting Yang Lin,

Zhen Chen,

Gang Chen,

Wei-Chi Wang,

Traci Marin,

TzuPin Shentu,

Liang Wen,

Brendan Gongol,

Wei Sun,

Xiao Liang,

Ju Chen,

HsienDa Huang,

Joao H. F. Pedra,

David A. Johnson,

John Y.J. Shyy

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002714

Subject(s) - inflammasome , endothelium , microbiology and biotechnology , innate immune system , inflammation , sterol regulatory element binding protein , endothelial dysfunction , nadph oxidase , endothelial stem cell , medicine , immunology , immune system , biology , sterol , cholesterol , biochemistry , reactive oxygen species , in vitro

The molecular basis for the focal nature of atherosclerotic lesions is poorly understood. Here, we explored whether disturbed flow patterns activate an innate immune response to form the NLRP3 inflammasome scaffold in vascular endothelial cells via sterol regulatory element binding protein 2 (SREBP2).

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