Function and Distribution of Apolipoprotein A1 in the Artery Wall Are Markedly Distinct From Those in Plasma | Zendy

Joseph A. DiDonato | Zendy; Ying Huang | Zendy; Kulwant S. Aulak | Zendy; Orli EvenOr | Zendy; Gary S. Gerstenecker | Zendy; Valentin Gogonea | Zendy; Yuping Wu | Zendy; Paul L. Fox | Zendy; W.H. Wilson Tang | Zendy; Edward F. Plow | Zendy; Jonathan D. Smith | Zendy; Edward A. Fisher | Zendy; Stanley L. Hazen | Zendy

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Function and Distribution of Apolipoprotein A1 in the Artery Wall Are Markedly Distinct From Those in Plasma

Author(s) -

Joseph A. DiDonato,

Ying Huang,

Kulwant S. Aulak,

Orli EvenOr,

Gary S. Gerstenecker,

Valentin Gogonea,

Yuping Wu,

Paul L. Fox,

W.H. Wilson Tang,

Edward F. Plow,

Jonathan D. Smith,

Edward A. Fisher,

Stanley L. Hazen

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002624

Subject(s) - apolipoprotein a1 , apolipoprotein b , aorta , lipoprotein , cholesterol , medicine , lecithin , sterol o acyltransferase , tangier disease , endocrinology , high density lipoprotein , biochemistry , biology , abca1 , transporter , gene

Prior studies show that apolipoprotein A1 (apoA1) recovered from human atherosclerotic lesions is highly oxidized. Ex vivo oxidation of apoA1 or high-density lipoprotein (HDL) cross-links apoA1 and impairs lipid binding, cholesterol efflux, and lecithin-cholesterol acyltransferase activities of the lipoprotein. Remarkably, no studies to date directly quantify either the function or HDL particle distribution of apoA1 recovered from the human artery wall.

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