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Phenotypic modulation or switching of vascular smooth muscle cells from a contractile/quiescent to a proliferative/synthetic phenotype plays a key role in vascular proliferative disorders such as atherosclerosis and restenosis. Although several calcium handling proteins that control differentiation of smooth muscle cells have been identified, the role of protein phosphatase inhibitor 1 (I-1) in the acquisition or maintenance of the contractile phenotype modulation remains unknown.

circulation

Synergistic Role of Protein Phosphatase Inhibitor 1 and Sarco/Endoplasmic Reticulum Ca <sup>2+</sup> -ATPase in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells

Synergistic Role of Protein Phosphatase Inhibitor 1 and Sarco/Endoplasmic Reticulum Ca 2+ -ATPase in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells

Synergistic Role of Protein Phosphatase Inhibitor 1 and Sarco/Endoplasmic Reticulum Ca ²⁺ -ATPase in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells