Synergistic Role of Protein Phosphatase Inhibitor 1 and Sarco/Endoplasmic Reticulum Ca 2+ -ATPase in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells | Zendy

Larissa Lipskaia | Zendy; Régis Bobe | Zendy; Jiqiu Chen | Zendy; Irene C. Turnbull | Zendy; José J. López | Zendy; Elise Merlet | Zendy; Dongtaq Jeong | Zendy; Ioannis Karakikes | Zendy; Alexandra S. Ross | Zendy; Lifan Liang | Zendy; Nathalie Mougenot | Zendy; Fabrice Atassi | Zendy; AnneMarie Lompré | Zendy; Sima T. Tarzami | Zendy; Jason C. Kovacic | Zendy; Evangelia G. Kranias | Zendy; Roger J. Hajjar | Zendy; Lahouaria Hadri | Zendy

Open Access

Synergistic Role of Protein Phosphatase Inhibitor 1 and Sarco/Endoplasmic Reticulum Ca ²⁺ -ATPase in the Acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells

Author(s) -

Larissa Lipskaia,

Régis Bobe,

Jiqiu Chen,

Irene C. Turnbull,

José J. López,

Elise Merlet,

Dongtaq Jeong,

Ioannis Karakikes,

Alexandra S. Ross,

Lifan Liang,

Nathalie Mougenot,

Fabrice Atassi,

AnneMarie Lompré,

Sima T. Tarzami,

Jason C. Kovacic,

Evangelia G. Kranias,

Roger J. Hajjar,

Lahouaria Hadri

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002565

Subject(s) - phospholamban , endoplasmic reticulum , vascular smooth muscle , microbiology and biotechnology , medicine , endocrinology , myocardin , phosphatase , biology , phosphorylation , biochemistry , gene expression , serum response factor , smooth muscle , gene

Phenotypic modulation or switching of vascular smooth muscle cells from a contractile/quiescent to a proliferative/synthetic phenotype plays a key role in vascular proliferative disorders such as atherosclerosis and restenosis. Although several calcium handling proteins that control differentiation of smooth muscle cells have been identified, the role of protein phosphatase inhibitor 1 (I-1) in the acquisition or maintenance of the contractile phenotype modulation remains unknown.

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