Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary Hypertension | Zendy

Nathalie Mouraret | Zendy; Élisabeth Marcos | Zendy; Shariq Abid | Zendy; Guillaume GaryBobo | Zendy; Mirna Saker | Zendy; Amal Houssaïni | Zendy; JeanLuc DuboisRandé | Zendy; Laurent Boyer | Zendy; Jorge Boczkowski | Zendy; Geneviève Dérumeaux | Zendy; Valérie Amsellem | Zendy; Serge Adnot | Zendy

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Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary Hypertension

Author(s) -

Nathalie Mouraret,

Élisabeth Marcos,

Shariq Abid,

Guillaume GaryBobo,

Mirna Saker,

Amal Houssaïni,

JeanLuc DuboisRandé,

Laurent Boyer,

Jorge Boczkowski,

Geneviève Dérumeaux,

Valérie Amsellem,

Serge Adnot

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002434

Subject(s) - medicine , pulmonary hypertension , lung , cardiology , cancer research

Induction of cellular senescence through activation of the p53 tumor suppressor protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin ligase MDM2 (murine double minute 2), a negative p53 regulator, from interacting with p53. We hypothesized that cell senescence induced by Nutlin-3a exerted therapeutic effects in pulmonary hypertension (PH) by limiting the proliferation of pulmonary artery smooth muscle cells (PA-SMCs).

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