Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease | Zendy

Maria SabaterLleal | Zendy; Jie Huang | Zendy; Daniel I. Chasman | Zendy; Silvia Naitza | Zendy; Abbas Dehghan | Zendy; Andrew D. Johnson | Zendy; Alexander Teumer | Zendy; Alex P. Reiner | Zendy; Lasse Folkersen | Zendy; Saonli Basu | Zendy; Alicja R. Rudnicka | Zendy; Stella Trompet | Zendy; Anders Mälarstig | Zendy; Jens Baumert | Zendy; Joshua C. Bis | Zendy; Xiuqing Guo | Zendy; JoukeJan Hottenga | Zendy; So-Youn Shin | Zendy; Lorna M. Lopez | Zendy; Jari Lahti | Zendy; Toshiko Tanaka | Zendy; Lisa R. Yanek | Zendy; Tiphaine OudotMellakh | Zendy; James F. Wilson | Zendy; Pau Navarro | Zendy; Jennifer E. Huffman | Zendy; Tatijana Zemunik | Zendy; Susan Redline | Zendy; Reena Mehra | Zendy; Dražen Pulanić | Zendy; Igor Rudan | Zendy; Alan F. Wright | Zendy; Ivana Kolčić | Zendy; Ozren Polašek | Zendy; Sarah H. Wild | Zendy; Harry Campbell | Zendy; J. David Curb | Zendy; Robert B. Wallace | Zendy; Simin Liu | Zendy; Charles B. Eaton | Zendy; Diane M. Becker | Zendy; Lewis C. Becker | Zendy; Stefania Bandinelli | Zendy; Katri Räikkönen | Zendy; Elisabeth Widén | Zendy; Aarno Palotie | Zendy; Myriam Fornage | Zendy; David Green | Zendy; Myron D. Gross | Zendy; Gail Davies | Zendy; Sarah E. Harris | Zendy; David C. Liewald | Zendy; John M. Starr | Zendy; Frances M. K. Williams | Zendy; Peter J. Grant | Zendy; Timothy D. Spector | Zendy; Rona J. Strawbridge | Zendy; Angela Silveira | Zendy; Bengt Sennblad | Zendy; Fernando Rivadeneira | Zendy; André G. Uitterlinden | Zendy; Oscar H. Franco | Zendy; Albert Hofman | Zendy; Jenny van Dongen | Zendy; Gonneke Willemsen | Zendy; Dorret I. Boomsma | Zendy; Jie Yao | Zendy; Nancy S. Jenny | Zendy; Talin Haritunians | Zendy; Barbara McKnight | Zendy; Thomas Lumley | Zendy; Kent D. Taylor | Zendy; Jerome I. Rotter | Zendy; Bruce M. Psaty | Zendy; Annette Peters | Zendy; Christian Gieger | Zendy; Thomas Illig | Zendy; Anne Grotevendt | Zendy; Georg Homuth | Zendy; Henry Völzke | Zendy; Thomas Köcher | Zendy; Anuj Goel | Zendy; Maria Grazia Franzosi | Zendy; Udo Seedorf | Zendy; Robert Clarke | Zendy; Maristella Steri | Zendy; Kirill V. Tarasov | Zendy; Serena Sanna | Zendy; David Schlessinger | Zendy; David J. Stott | Zendy; Naveed Sattar | Zendy; Brendan M. Buckley | Zendy; Ann Rumley | Zendy; Gordon Lowe | Zendy; Wendy L. McArdle | Zendy; MingHuei Chen | Zendy; Geoffrey H. Tofler | Zendy; Jaejoon Song | Zendy; Eric Boerwinkle | Zendy; Aaron R. Folsom | Zendy; Lynda M. Rose | Zendy; Anders FrancoCereceda | Zendy; Martina Teichert | Zendy; M. Arfan Ikram | Zendy; Thomas H. Mosley | Zendy; Steve Bevan | Zendy; Martin Dichgans | Zendy; Peter M. Rothwell | Zendy; Cathie Sudlow | Zendy; Jemma C. Hopewell | Zendy; John C. Chambers | Zendy; Danish Saleheen | Zendy; Jaspal S. Kooner | Zendy; John Danesh | Zendy; Christopher P. Nelson | Zendy; Jeanette Erdmann | Zendy; Muredach P. Reilly | Zendy; Sekar Kathiresan | Zendy; Heribert Schunkert | Zendy; PierreEmmanuel Morange | Zendy; Luigi Ferrucci | Zendy; Johan G. Eriksson | Zendy; David R. Jacobs | Zendy; Ian J. Deary | Zendy; Nicole Soranzo | Zendy; Jacqueline C.M. Witteman | Zendy; Eco J. C. de Geus | Zendy; Russell P. Tracy | Zendy; Caroline Hayward | Zendy; Wolfgang Köenig | Zendy; Francesco Cucca | Zendy; J. Wouter Jukema | Zendy; Per Eriksson | Zendy; Sudha Seshadri | Zendy; Hugh S. Markus | Zendy; Hugh Watkins | Zendy; Nilesh J. Samani | Zendy; Henri Wallaschofski | Zendy; Nicholas L. Smith | Zendy; DavidAlexandre Trégouët | Zendy; Paul M. Ridker | Zendy; Weihong Tang | Zendy; David P. Strachan | Zendy; Anders Hamsten | Zendy; Christopher J. O’Donnell | Zendy

Open Access

Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

Author(s) -

Maria SabaterLleal,

Jie Huang,

Daniel I. Chasman,

Silvia Naitza,

Abbas Dehghan,

Andrew D. Johnson,

Alexander Teumer,

Alex P. Reiner,

Lasse Folkersen,

Saonli Basu,

Alicja R. Rudnicka,

Stella Trompet,

Anders Mälarstig,

Jens Baumert,

Joshua C. Bis,

Xiuqing Guo,

JoukeJan Hottenga,

So-Youn Shin,

Lorna M. Lopez,

Jari Lahti,

Toshiko Tanaka,

Lisa R. Yanek,

Tiphaine OudotMellakh,

James F. Wilson,

Pau Navarro,

Jennifer E. Huffman,

Tatijana Zemunik,

Susan Redline,

Reena Mehra,

Dražen Pulanić,

Igor Rudan,

Alan F. Wright,

Ivana Kolčić,

Ozren Polašek,

Sarah H. Wild,

Harry Campbell,

J. David Curb,

Robert B. Wallace,

Simin Liu,

Charles B. Eaton,

Diane M. Becker,

Lewis C. Becker,

Stefania Bandinelli,

Katri Räikkönen,

Elisabeth Widén,

Aarno Palotie,

Myriam Fornage,

David Green,

Myron D. Gross,

Gail Davies,

Sarah E. Harris,

David C. Liewald,

John M. Starr,

Frances M. K. Williams,

Peter J. Grant,

Timothy D. Spector,

Rona J. Strawbridge,

Angela Silveira,

Bengt Sennblad,

Fernando Rivadeneira,

André G. Uitterlinden,

Oscar H. Franco,

Albert Hofman,

Jenny van Dongen,

Gonneke Willemsen,

Dorret I. Boomsma,

Jie Yao,

Nancy S. Jenny,

Talin Haritunians,

Barbara McKnight,

Thomas Lumley,

Kent D. Taylor,

Jerome I. Rotter,

Bruce M. Psaty,

Annette Peters,

Christian Gieger,

Thomas Illig,

Anne Grotevendt,

Georg Homuth,

Henry Völzke,

Thomas Köcher,

Anuj Goel,

Maria Grazia Franzosi,

Udo Seedorf,

Robert Clarke,

Maristella Steri,

Kirill V. Tarasov,

Serena Sanna,

David Schlessinger,

David J. Stott,

Naveed Sattar,

Brendan M. Buckley,

Ann Rumley,

Gordon Lowe,

Wendy L. McArdle,

MingHuei Chen,

Geoffrey H. Tofler,

Jaejoon Song,

Eric Boerwinkle,

Aaron R. Folsom,

Lynda M. Rose,

Anders FrancoCereceda,

Martina Teichert,

M. Arfan Ikram,

Thomas H. Mosley,

Steve Bevan,

Martin Dichgans,

Peter M. Rothwell,

Cathie Sudlow,

Jemma C. Hopewell,

John C. Chambers,

Danish Saleheen,

Jaspal S. Kooner,

John Danesh,

Christopher P. Nelson,

Jeanette Erdmann,

Muredach P. Reilly,

Sekar Kathiresan,

Heribert Schunkert,

PierreEmmanuel Morange,

Luigi Ferrucci,

Johan G. Eriksson,

David R. Jacobs,

Ian J. Deary,

Nicole Soranzo,

Jacqueline C.M. Witteman,

Eco J. C. de Geus,

Russell P. Tracy,

Caroline Hayward,

Wolfgang Köenig,

Francesco Cucca,

J. Wouter Jukema,

Per Eriksson,

Sudha Seshadri,

Hugh S. Markus,

Hugh Watkins,

Nilesh J. Samani,

Henri Wallaschofski,

Nicholas L. Smith,

DavidAlexandre Trégouët,

Paul M. Ridker,

Weihong Tang,

David P. Strachan,

Anders Hamsten,

Christopher J. O’Donnell

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002251

Subject(s) - genome wide association study , medicine , fibrinogen , genetic association , single nucleotide polymorphism , coronary artery disease , disease , bioinformatics , genetics , oncology , gene , biology , genotype

Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (<2%) of its variation.

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