Ultralarge von Willebrand Factor Fibers Mediate Luminal Staphylococcus aureus Adhesion to an Intact Endothelial Cell Layer Under Shear Stress | Zendy

Karin I. Pappelbaum | Zendy; Christian Gorzelanny | Zendy; Sandra Grässle | Zendy; Jan Suckau | Zendy; Matthias W. Laschke | Zendy; Markus Bischoff | Zendy; Corinne Bauer | Zendy; Marina SchorppKistner | Zendy; Christopher Weidenmaier | Zendy; Reinhard Schneppenheim | Zendy; Tobias Obser | Zendy; Bhanu Sinha | Zendy; Stefan W. Schneider | Zendy

Open Access

Ultralarge von Willebrand Factor Fibers Mediate Luminal Staphylococcus aureus Adhesion to an Intact Endothelial Cell Layer Under Shear Stress

Author(s) -

Karin I. Pappelbaum,

Christian Gorzelanny,

Sandra Grässle,

Jan Suckau,

Matthias W. Laschke,

Markus Bischoff,

Corinne Bauer,

Marina SchorppKistner,

Christopher Weidenmaier,

Reinhard Schneppenheim,

Tobias Obser,

Bhanu Sinha,

Stefan W. Schneider

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.002008

Subject(s) - von willebrand factor , microbiology and biotechnology , von willebrand disease , adamts13 , endothelium , chemistry , staphylococcus aureus , ex vivo , thrombospondin , knockout mouse , platelet , immunology , biology , bacteria , metalloproteinase , endocrinology , matrix metalloproteinase , biochemistry , receptor , in vitro , genetics

During pathogenesis of infective endocarditis, Staphylococcus aureus adherence often occurs without identifiable preexisting heart disease. However, molecular mechanisms mediating initial bacterial adhesion to morphologically intact endocardium are largely unknown.

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