Ca 2+ /Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca 2+ Leak in Human Cardiac Pathology | Zendy

Thomas H. Fischer | Zendy; Jonas Herting | Zendy; Theodor Tirilomis | Zendy; André Renner | Zendy; Stefan Neef | Zendy; Karl Toischer | Zendy; David Ellenberger | Zendy; Anna Förster | Zendy; Jan D. Schmitto | Zendy; Jan Gummert | Zendy; Friedrich A. Schöndube | Zendy; Gerd Hasenfuß | Zendy; Lars S. Maier | Zendy; Samuel Sossalla | Zendy

Open Access

Ca ²⁺ /Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca ²⁺ Leak in Human Cardiac Pathology

Author(s) -

Thomas H. Fischer,

Jonas Herting,

Theodor Tirilomis,

André Renner,

Stefan Neef,

Karl Toischer,

David Ellenberger,

Anna Förster,

Jan D. Schmitto,

Jan Gummert,

Friedrich A. Schöndube,

Gerd Hasenfuß,

Lars S. Maier,

Samuel Sossalla

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.001746

Subject(s) - ryanodine receptor 2 , calmodulin , medicine , ryanodine receptor , endocrinology , protein kinase a , endoplasmic reticulum , muscle hypertrophy , phosphorylation , kinase , calcium , biology , microbiology and biotechnology

Sarcoplasmic reticulum (SR) Ca(2+) leak through ryanodine receptor type 2 (RyR2) dysfunction is of major pathophysiological relevance in human heart failure (HF); however, mechanisms underlying progressive RyR2 dysregulation from cardiac hypertrophy to HF are still controversial.

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