Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia | Zendy

Keqing Wang | Zendy; Shakil Ahmad | Zendy; Meng Cai | Zendy; Jillian Rennie | Zendy; Takeshi Fujisawa | Zendy; F. Crispi | Zendy; James Baily | Zendy; Mark R. Miller | Zendy; Melissa Cudmore | Zendy; Patrick W. F. Hadoke | Zendy; Rui Wang | Zendy; E. Gratacós | Zendy; Irina A. Buhimschi | Zendy; Catalin S. Buhimschi | Zendy; Asif Ahmed | Zendy

Open Access

Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia

Author(s) -

Keqing Wang,

Shakil Ahmad,

Meng Cai,

Jillian Rennie,

Takeshi Fujisawa,

F. Crispi,

James Baily,

Mark R. Miller,

Melissa Cudmore,

Patrick W. F. Hadoke,

Rui Wang,

E. Gratacós,

Irina A. Buhimschi,

Catalin S. Buhimschi,

Asif Ahmed

Publication year - 2013

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.113.001631

Subject(s) - preeclampsia , soluble fms like tyrosine kinase 1 , placentation , trophoblast , umbilical vein , placenta , medicine , endocrinology , cystathionine beta synthase , fetus , cystathionine gamma lyase , andrology , placental growth factor , vascular endothelial growth factor , pregnancy , biology , enzyme , in vitro , biochemistry , genetics , cysteine , vegf receptors

The exact etiology of preeclampsia is unknown, but there is growing evidence of an imbalance in angiogenic growth factors and abnormal placentation. Hydrogen sulfide (H2S), a gaseous messenger produced mainly by cystathionine γ-lyase (CSE), is a proangiogenic vasodilator. We hypothesized that a reduction in CSE activity may alter the angiogenic balance in pregnancy and induce abnormal placentation and maternal hypertension.

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